1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2Radiology, Harvard Medical School, Boston, MA, United States
350 um isotropic imaging at 3 T requires very long scan times, and subject motion is a critical impediment. We demonstrate the use of volumetric navigators (vNavs) for prospective motion and frequency correction, and the use of inner-loop GRAPPA in a MPRAGE to maintain desirable contrast as seen at 1mm. Combined, these techniques allow successful 350 um isotropic imaging of a healthy volunteer without additional restraint.