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Abstract #0279

Detection of Tissue Inflammatory Change with Multifrequency 3-D Magnetic Resonance Elastography

Meng Yin1, Kevin J. Glaser1, Jun Chen1, Yogesh K. Mariappan1, Jayant A. Talwalkar2, Richard L. Ehman1

1Radiology, Mayo Clinic, Rochester, MN, United States; 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

To investigate the utility of MRE derived mechanical properties in detecting hepatic inflammation, we performed multifrequency 3-D/3-axis MRE technique on poroelastic phantoms and 87 patients with biopsy-proven chronic liver disease. Results demonstrated systematic variations in mechanical properties with increased interstitial fluid pressure, with delta (acrTan(G/G)) the most promising. These findings offer preliminary evidence of the potential to extend MRE to distinguish and independently assess necroinflammatory and fibrotic processes.