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Abstract #0280

Assessing Liver Fibrosis: Comparison of Arterial Enhancement Fraction and Diffusion-Weighted Imaging

David Bonekamp1, Susanne Bonekamp1, Hsin-You Ou1, Michael S. Torbenson2, Celia Pamela Corona-Villalobos1, Ihab R. Kamel1

1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 2Department of Pathology, Johns Hopkins University, Baltimore, MD, United States

Arterial Enhancement Fraction (AEF) was compared to apparent diffusion coefficient (ADC) for assessment of hepatic fibrosis in chronic liver disease. Quantitative mapping of contrast enhanced MRI-derived AEF were used to grade fibrosis according METAVIR criteria. AEF and ADC values differed significantly between fibrosis stages. ROC analysis showed improved discrimination of fibrosis stages for AEF compared to ADC. AEF can be used for accurate noninvasive prediction of the presence of liver fibrosis stage, and its predictive value is increased with concomitant use of ADC in the form of a weighted composite score of AEF and ADC.