Abstract #0322

Subcellular Distribution of Manganese and Its Impact on Mitochondrial Function in Rat Cardiac Myocytes

Ya Chen¹, Mariana G. Rosca², Charles L. Hoppel²,³, Xin Yu¹

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; ²School of Medicine, Case Western Reserve University, Cleveland, OH, United States; ³Department of Pharmacology, Case Western Reserve University, Cleveland, OH, United States

This study aims to elucidate the mechanisms leading to long Mn2+ retention in cardiac myocytes. Subcellular distribution of Mn2+ was delineated by ICP-OES. The impact of Mn2+ accumulation on mitochondrial respiration was also assessed by isolated mitochondrial studies.