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Abstract #0323

Feasibility of Cyclic Myocardial Perfusion Variation Assessment During Adenosine-Induced Stress in Rats

Thomas Troalen1, Thibaut Capron1, Monique Bernard2, Patrick J. Cozzone2, Frank Kober1

1Centre de Rsonance Magntique Biologique et Mdicale (CRMBM), UMR CNRS N7339, Facult de Mdecine, Aix-Marseille Universit, Marseille, France; 2Centre de Rsonance Magntique Biologique et Mdicale (CRMBM), Aix-Marseille Universit, Marseille, France

This study presents the use of a recently proposed arterial spin labeling method for assessing cyclic variations of myocardial blood flow (MBF) in small rodents. An ECG-gated steady-pulsed labeling approach was combined with simultaneous readout over the cardiac cycle using cine-FLASH to obtain cyclic temporally resolved MBF maps across the cardiac cycle with 6 ms resolution. The new protocol was carried out on one Wistar rat at rest and during intravenous adenosine-induced stress. Perfusion was found higher during stress, but the relative variation was slightly lower compared to rest.