Joseph H. Rosenberg1, Chandler R. Sours1, Jiachen Zhuo1, Elijah O. George1, 2, Rao P. Gullapalli1
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; 2Department of Bioengineering, University of Maryland, College Park, MD, United States
Mild traumatic brain injury (mTBI) patients received a resting state fMRI scan and completed the Automated Neuropsychological Assessment Metrics (ANAM) at the acute (&[le]10days) and sub-acute (1 month) stages of injury. During the sub-acute stage, mTBI patients demonstrated reduced interhemispheric functional connectivity (IH-FC) in both the thalamus and the dorsolateral prefrontal cortex, as well as deficits on the ANAM, compared to matched controls. Patients reporting Post-Concussive Syndrome (PCS) demonstrated a significant reduction in thalamic IH-FC from the acute stage to the sub-acute stage. PCS patients also performed significantly worse on the ANAM than those without.