Abstract #0329

Interhemispheric Functional Connectivity in the Thalamus and Dorsolateral Prefrontal Cortex of Mild TBI Patients with and Without Post-Concussive Syndrome

Joseph H. Rosenberg¹, Chandler R. Sours¹, Jiachen Zhuo¹, Elijah O. George¹,², Rao P. Gullapalli¹

¹Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; ²Department of Bioengineering, University of Maryland, College Park, MD, United States

Mild traumatic brain injury (mTBI) patients received a resting state fMRI scan and completed the Automated Neuropsychological Assessment Metrics (ANAM) at the acute (&[le]10days) and sub-acute (1 month) stages of injury. During the sub-acute stage, mTBI patients demonstrated reduced interhemispheric functional connectivity (IH-FC) in both the thalamus and the dorsolateral prefrontal cortex, as well as deficits on the ANAM, compared to matched controls. Patients reporting Post-Concussive Syndrome (PCS) demonstrated a significant reduction in thalamic IH-FC from the acute stage to the sub-acute stage. PCS patients also performed significantly worse on the ANAM than those without.