1Radiology, Washington University in Saint Louis, Saint Louis, MO, United States; 2Neurology, Washington University in Saint Louis, Saint Louis, MO, United States
Stroke is a major health concern in the US. It is becoming increasingly apparent that a brain-wide assessment of functional connections may provide better insight into recovery potential than assessment of anatomic infarction. While recent findings suggest that bilateral connectivity is associated with recovery, signal regression can influence interpretation of functional connectivity patterns. Neglecting to distinguish unique signals within and across hemispheres may confound potentially recovery-relevant information. We applied a novel functional connectivity optical intrinsic signal imaging technique to a mouse model of ischemic stroke to evaluate altered regional hemodynamics and how they can affect measurements of connectivity after stroke.