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Abstract #0332

Resting-State MRI Detects Donepezil Effects on Functional Connectivity and Maze Learning in Rodent Brain

Fatima Ali Nasrallah1, Xuan Vinh To1, Tovia Yun Jie Ng1, Kai-Hsiang Chuang1

1Magnetic Resonance Imaging Group, A*Star Biomedical Research Institutes, Singapore, Singapore

Functional connectivity MRI has emerged as a means to map intrinsic brain networks without the need of explicit tasks. We investigated the effects of Donepezil on brain function using Atlantis Watermaze and functional connectivity MRI. Donepezil is a popular treatment for improving cognitive function in Alzheimers disease patients. We show that the alteration of the functional connectivity pattern after donepezil treatment is closely associated with cognitive improvement.