Abstract #0333

Functional and Structural Connectivity Impairments Precede Plaque Deposition in a Transgenic Mouse Model of Alzheimers Disease

Joanes Grandjean¹, Pan He², Aileen Schrter¹, Markus Rudin¹,³

¹Inst. f. Biomedizinische Technik, ETH and University Zrich, Zrich, Switzerland; ²ETH Zrich, Zrich, Switzerland; ³Institute of Pharmacology and Toxicology, University of Zrich, 8057, Switzerland

Functional connectivity (FC) and fractional anisotropy (FA) was measured in ArcAbeta mouse model of Alzheimer's disease at 5, 8, 11, 19 and 21 months of age. Decrease in FC and FA was detectable in 5 months old mice compared to wild-type, in the sensory-motor networks for FC and in the corpus callosum for FA. Changes in FC and FA remained constant over the progression of the disease until the last measurements at 21 months. ArcAbeta develop amyloid plaques starting at 7 months. Our results suggest that changes in FC and FA precede amyloid plaque deposition in the ArcAbeta mouse model.