Bhavana S. Solanky1, Frank Riemer1, Xavier Golay2, Claudia Angela M. Wheeler-Kingshott1
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Department of Brain Repair and Rehabilitation, University College London, London, United Kingdom
23Na-MRS has been suggested for 23Na quantification in the spinal cord using ISIS. However, the inversion pulses of ISIS are typically long hypersecant (HS) pulses. This has implications when dealing with short T2 metabolites such as sodium. Hence the effects of both HS and shorter sinc-guass (SG) pulses are simulated and tested in vivo. Here we present two sequences 1) a Fast HS based pulse sequence and 2) a Fast UltraShort T2 Sensitive ISIS sequence which has the potential to be more sensitive to short T2 components for 23Na quantification in the spinal cord.