Abstract #0351

FUSS- Fast Ultrashort T2 Sensitive Sodium MRS of the Spinal Cord

Bhavana S. Solanky¹, Frank Riemer¹, Xavier Golay², Claudia Angela M. Wheeler-Kingshott¹

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; ²Department of Brain Repair and Rehabilitation, University College London, London, United Kingdom

²³Na-MRS has been suggested for ²³Na quantification in the spinal cord using ISIS. However, the inversion pulses of ISIS are typically long hypersecant (HS) pulses. This has implications when dealing with short T₂ metabolites such as sodium. Hence the effects of both HS and shorter sinc-guass (SG) pulses are simulated and tested in vivo. Here we present two sequences 1) a Fast HS based pulse sequence and 2) a Fast UltraShort T₂ Sensitive ISIS sequence which has the potential to be more sensitive to short T₂ components for ²³Na quantification in the spinal cord.