Abstract #0352

Pool Size Ratio Mapping in the Spine from a Single Magnetization Transfer Measurement

Alex K. Smith¹,², Richard D. Dortch²,³, Seth A. Smith²,³

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; ²Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; ³Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

A method to perform qMT in the spine with a single off-resonance measurement was developed. ROIs were chosen in the lateral and dorsal columns of the spine, and in the grey matter. A single measurement model was used to fit the PSR at different off-resonance frequencies and saturation angles. The PSRs from these fits were then compared with the PSR from a full fit model. These results suggest that the PSR can be robustly quantified in healthy cervical spinal cord using only a single off-resonance measurement.