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Abstract #0356

Monitoring Skeletal Muscle Regeneration and Dystrophy in Mice Using T2 and Diffusion Tensor MRI and Fiber Tracking

Khan Hekmatyar1, Steven J. Foltz2, Marisa J. Fortunato2, Aaron M. Beedle2

1BioImaging Research Center/Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States; 2Department of Pharmaceutical and Biomedical Sciences, University of Georgia College of Pharmacy, Athens, GA, United States

Quantitative T2 measured in our dystrophic mouse model has shown distinct dystrophic pathology that correlates with histological measurements at young, but not older ages. Here we explored the role of regenerating muscle fibers in altering T2 measurements in muscle and sought to identify other parameters to provide complimentary information about the cascade of events occurring after muscle damage. We find that DTI and fiber tracking is a promising means to evaluate muscle fiber regeneration and dystrophic pathology.