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Abstract #0423

Amide Proton Transfer Imaging of High Intensity Focused Ultrasound-Treated Tumor Tissue

Stefanie J.C.G. Hectors1, Igor Jacobs1, Gustav J. Strijkers1, Klaas Nicolay1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

The effects of HIFU treatment on tumor APT intensity were assessed in a murine tumor model. Regions with decreased APT intensity were observed after HIFU treatment. These regions correlated spatially to areas of non-viable, necrotic tumor tissue observed in histology. Analysis of the tumor APT intensity distribution showed a pronounced shift towards lower APT intensity values after HIFU. The fractions of pixels within the defined HIFU-related APT intensity range (-10 to -2%) significantly increased by HIFU treatment. These results suggest that APT imaging may serve as a new biomarker for identification of HIFU-treated tumor tissue.