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Abstract #0424

GlucoCEST for the Detection of Human Xenografts Glioblastoma at Early Stage.

Francisco Torrealdea1, Marilena Rega1, Angela Richard-Loendt1, Sebastian Brandner1, David L. Thomas1, Simon Walker-Samuel2, Xavier Golay3

1Institute of Neurology, UCL, London, Greater London, United Kingdom; 2Centre for Advanced Biomedical Imaging, UCL, London, Greater London, United Kingdom; 3Institute of Neurology, University College London, London, Greater London, United Kingdom

GlucoCEST has been shown to detect exogenously administrated glucose in tumours and to correlate with FDG PET. In this study we investigate the feasibility of the technique for the detection of xenograft human glioblastoma. Comparison of glucoCEST measurements with histology and T2weighted images, suggests that the technique is sensitive enough to detect brain tumours at an early stage, before the disruption of tissue microestructure has occurred. It also allows dynamic measurements of tumour metabolism which could potentially be used for the characterization of glial tumour grade.