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Abstract #0449

3D MRI Microscopy of the Lens, Vitreous, and Anterior Chamber Volumes in Normal Mouse Eyes and Eyes with Retinal Degeneration

Eric R. Muir1, Timothy O. Duong2

1Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States; 2Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

Retinitis pigmentosa (RP), which causes photoreceptor death and blindness and affects 1.5 million people worldwide, is characterized by progressive loss of the retina. While the retinal degeneration is well characterized, it is unclear how other structures of the eye in RP are affected. The goal of this study was to develop a 3D MRI approach to image the whole mouse eye in vivo at 47x78x79 &[micro]m with high contrast and sensitivity using balanced steady state free precession. We applied this approach to quantify volumes of the lens, vitreous, and anterior chamber in a mouse model of RP.