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Abstract #0475

Quantification of Intra-Procedural Gland Motion During Transperineal MRI-Guided Prostate Biopsy

Andriy Fedorov1, Kemal Tuncali1, Tobias Penzkofer1, 2, Junichi Tokuda1, Sang-Eun Song1, Nobuhiko Hata1, Clare Tempany1

1Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; 2Department of Diagnostic and Interventional Radiology, RWTH Aachen University Hospital , Aachen, North Rhine-Westphalia, Germany

Interventional applications of MRI in PCa management include MRI-guided core needle biopsy that can be recommended for some patient populations, and may lead to improved accuracy of cancer detection. In this work we apply deformable registration retrospectively to recover and quantify intra-procedural motion of the pelvis and prostate gland. Our results show significant motion of the gland, which cannot be fully recovered by compensating for pelvis motion. This can lead to significant errors between the planned and true location of the biopsy target. Application of intra-procedural registration is recommended for intra-procedural quantification and recovery of target motion.