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Abstract #0476

SPIO-Labeled 90Y Microspheres Permit Accurate Quantification of Macroscopic Intra-Hepatic Biodistribution

Weiguo Li1, 2, Zhuoli Zhang1, Yang Guo1, Jodi Nicolai1, Reed A. Omary1, Andrew C. Larson1

1Radiology, Northwestern University, Chicago, IL, United States; 2Research Resource Center, University of Illinois at Chicago, Chicago, IL, United States

Visualization and quantification of Yttrium-90 (90Y) microsphere biodistribution using conventional radiologic modalities is challenging. Whereas labeling 90Y microspheres with SPIOs offers the potential to use MRI to visualize in vivo biodistribution, optimization of the amount of SPIO included within these microspheres may be critical. In this study, we have demonstrated the potential to optimize SPIO content for future studies intended to quantify microsphere concentrations in vivo; we found that spheres with 2% SPIO contents will be ideal candidates for in vivo studies.