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Abstract #0515

Combined Visualization of ADC Diffusion Maps and CBV Perfusion Maps in Patients with Newly Diagnosed Glioblastoma

Alexander Radbruch1, 2, Kira Lutz1, Benedikt Wiestler3, Philipp Bumer1, Markus Graf2, Ralf Floca2, Wolfgang Wick3, Heinz Peter Schlemmer2, Martin Bendszus1, Sabine Heiland1

1Department of Neuroradiology, Heidelberg University Medical Center, Heidelberg, Germany; 2Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 3Department of Neurooncology, Heidelberg University Medical Center, Heidelberg, Germany

Areas of decreased apparent diffusion coefficient (MinADC) on diffusion MRI (DWI) and areas of increased cerebral blood volume (MaxCBV) on dynamic-susceptibility-contrast perfusion MRI (DSC) are supposed to present the most malignant parts of glioblastoma. However, it is still unclear if the identified regions on DWI and DSC overlap. We assessed 20 patients with glioblastoma with a new postprocessing technique and found an average overlap in 34.7 +/- 10.9 percent. Furthermore we found that areas of MaxCBV are located mostly in the enhancing region while areas of MinADC are located mostly in the surrounding area.