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Abstract #0516

Voxel-Wise Repeatability of Apparent Diffusion Coefficient in Patients with Newly Diagnosed Glioblastoma

Pavlina Polaskova1, Kourosh Jafari-Khouzani1, Alexander R. Guimaraes1, Steven M. Stufflebeam1, Patrick Y. Wen2, Tracy T. Batchelor3, Bruce R. Rosen1, Elizabeth R. Gerstner3, Jayashree Kalpathy-Cramer1

1Radiology, Athinoula A. Martinos Center for Biomedical Imaging / Massachusetts General Hospital, Charlestown, MA, United States; 2Neuro-oncology, Brigham and Women's Hospital / Harvard Medical School, Boston, MA, United States; 3Neurology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, United States

We assessed the voxel-wise repeatability of ADC values in patients with newly diagnosed glioblastoma in relation to functional diffusion mapping technique. Although the intra-class correlation coefficients are relatively high, the variability of the tumor values exceeds the thresholds for stable voxels, as proposed by functional diffusion mapping, suggesting the absolute thresholding be re-evaluated.