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Abstract #0588

Combined Spin and Gradient Echo Imaging Following Injection of USPIOs in Humans

Thomas Christen1, Deqiang Qiu1, Wendy W. Ni1, Heiko Schmiedeskamp1, Roland Bammer1, Michael E. Moseley1, Greg Zaharchuk1

1Radiology, Stanford University, Stanford, CA, United States

In the present study, we analysed the spin- and gradient echo contrast variations following injection of Ferumoxytol (an FDA-approved ultra-small paramagnetic iron oxide [USPIO] compound) in the human brain. The high magnetic susceptibility of ferumoxytol allow the acquisition of high quality spin-echo perfusion maps as well as parametric maps describing the vessel diameter and vessel density of the microvasculature. The long half-life of the contrast agent permits acquisitions at high spatial resolution.