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Abstract #0589

Determination of the Vascular Input Function Using Magnitude or Phase-Based MRI: Influence on Dynamic Contrast-Enhanced MRI Model Parameters in Carotid Plaques

Raf van Hoof1, 2, Martine Truijman1, 3, Evelien Hermeling1, 2, Robert J. van Oostenbrugge, 24, R.J. van der Geest5, A.H. Schreuder6, A.G.G.C. Korten7, N.P. van Orshoven8, Be Meens9, M.J.A.P. Daemen, 210, Joachim E. Wildberger1, 2, Walter H. Backes1, M.E. Kooi1, 2

1Radiology, Maastricht University Medical Center, Maastricht, Netherlands; 2Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands; 3Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, Netherlands; 4Neurology, Maastricht University Medical Center, Maastricht, Netherlands; 5Radiology, Leiden University Medical Center, Leiden, Netherlands; 6Neurology, Atrium Medical Centre, Heerlen, Netherlands; 7Neurology, Laurentius Medical Centre, Roermond, Netherlands; 8Neurology, Orbis Medical Centre, Sittard, Netherlands; 9Neurology, VieCuri Medical Centre, Venlo, Netherlands; 10Pathology, Academic Medical Centre, Amsterdam, Netherlands

A reliable vascular input function (VIF) is important for quantitative analysis of atherosclerotic carotid plaque microvasculature using dynamic contrast-enhanced (DCE) MRI. The purpose is 1) to compare magnitude-based VIF and phase-based VIF and 2) to investigate the influence of different VIFs on DCE MRI model parameters in carotid plaques. It is shown that magnitude-based VIF is strongly influenced by flow artefacts, leading to an underestimation of the peak Gadolinium concentration. Therefore, a phase-based VIF should be used for quantitative DCE MRI analysis.