Abstract #0617

Assessing Arterial Spin Labeled Perfusion MRI as an Early-Alzheimers Disease Marker Using the ADNI 2 Data

Ze Wang¹, Sandhitsu Das², David Wolk³, John A. Detre³

¹Psychiatry, University of Pennsylvania, Philadelphia, PA, United States; ²Radiology, University of Pennsylvania, Philadelphia, PA, United States; ³Neurology, University of Pennsylvania, Philadelphia, PA, United States

Noninvasively measuring the quantitative blood flow, ASL perfusion MRI can potentially be used as marker for progressive neurodegenerative disease like AD. Using the Alzheimers Disease Neuroimaging Initiative ASL data, we showed the first evidence of the sensitivity of ASL CBF to prodromal and early AD in a multi-site context; ASL CBF appeared to decrease inversely with degree of impairment which is consistent with prior work with FDG PET.