Abstract #0618

Regional CBF in Patients with AD and MCI: Effect of Apolipoprotein Epsilon4 Allele

Geon-Ho Jahng¹, Kyung-Mi Lee², Sun-Mi Kim³, Min-Ji Kim³, Eo-Jin Hwang³, Hyug-Gi Kim⁴, Hak-Young Rhee⁵, Chang-Woo Ryu¹, Wook Jin¹, Dal-Mo Yang¹, Ji Seon Park⁶

¹Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea; ²Radiology, Graduate College of of Medicine, Kyung Hee University, Seoul, Korea; ³Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea; ⁴Biomedical Engineering, Graduate College of Electronics and Information, Kyung Hee University, Youngin, Gyeonggi-do, Korea; ⁵Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea; ⁶Radiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea

To evaluate the effect of apolipoprotein E (APOE) epsilon 4 allele on regional cerebral perfusion (rCBF) changes, pulsed arterial spin labeling (ASL) imaging and isotropic volumetric T1-weighted imaging were scanned in 25 subjects with AD, 25 with amnestic mild cognitive impairment(MCI) and 25 cognitively normal(CN) subjects. All subjects were divided into carrier or noncarriers of the epsilon4 allele. In each subject group, we also evaluated the rCBF change between carrier and noncarrier groups. rCBF values were significantly reduced in the CN and AD groups, but increased in MCI in the carriers of the epsilon4 allele.