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Abstract #0629

Cerebral Aneurysm Wall Permeability, a New Parameter for Assessing Ruptue Risk

Parmede Vakil1, Sameer A. Ansari, Marie Wasliewski, Susanne Schnell, Hunt Batjer2, Christopher S. Eddleman2, Bernard R. Bendok3, Michael Markl, Timothy J. Carroll1

1Biomedical Engineering and Radiology, Northwestern University, Chicago, IL, United States; 2Neurosurgery, University of Texas Southwestern, Dallas, TX, United States; 3Neurosurgery, Northwestern University, Chicago, IL, United States

Cerebral Aneurysms pose a significant risk to the population at large with over 30,000 ruptures each year. Geometric shape indices and hemodynamic studies of blood velocity and wall shear stress provide non-invasive and quantifiable imaging metrics for assessing rupture risk. We have developed a model for studying wall permeability in cerebral aneurysms using DCE-MRI derived kinetic modeling of contrast agent leakage based on Tofts classic model. We have found that the derived non-invasive metrics Ktrans and leakage volume space which describe aneurysm leakiness may also be used for rupture risk assessment.