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Abstract #0630

Comprehensive Vessel Wall Imaging for Concomitant Extracranial and Intracranial Atherosclerotic Plaques in Symptomatic Patients Using Fast 3D Multicontrast Black-Blood MR Imaging Sequences

Xihai Zhao1, Rui Li1, Jinnan Wang2, Le He1, Zechen Zhou1, Xiping Gong3, Donghua Mi3, Xingquan Zhao3, Chun Yuan1, 4

1Center for Biomecial Imaging research & Department of Biomedical Engineering, Tsinghua University, Beijing, China; 22.Philips Research North America, Briarcliff Manor, NY, United States; 3Department of Neurology, Tiantan Hospital, Capical Medical University, Beijing, China; 4Department of Radiology, University of Washington, Seattle, WA, United States

Angiography studies have shown that intracranial and extracranial concomitant atherosclerotic diseases are common in stroke patients. However, stenosis-based approaches underestimate disease severity due to the phenomenon of positive remodeling. Recently proposed 3D vessel wall imaging sequences, such as MERGE, VISTA, and SNAP, may have the potential to perform comprehensive imaging for detection of concomitant plaques at intracranial and extracranial circulations. This study sought to assess neurovascular concomitant atherosclerosis using 3D multicontrast black-blood imaging sequences in symptomatic patients. We found that stroke patients frequently developed concomitant intracranial and extracranial atherosclerosis much more commonly than literature reports (74.1% vs. 43%).