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Abstract #0651

Non-Contrast-Enhanced Preoperative Assessment of Lung Perfusion in Patients with Non-Small-Cell Lung Cancer Using Fourier Decomposition Magnetic Resonance Imaging

Gregor Sommer1, 2, Michael Puderbach3, Marcel Koenigkam-Santos3, 4, Christopher Draenkow5, Claus-Peter Heussel3, Hans-Ulrich Kauczor6, Heinz-Peter Schlemmer2, Grzegorz Bauman7, 8

1Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland; 2Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 3Radiology, Thoraxklinik Heidelberg, Heidelberg, Germany; 4Radiology, University Hospital of the School of Medicine of Ribeirao Preto - University of Sao Paulo, Ribeirao Preto, Brazil; 5Surgery, Thoraxklinik Heidelberg, Heidelberg, Germany; 6Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; 7Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; 8Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

This study investigates non-contrast-enhanced Fourier decomposition MRI (FD MRI) as a tool for preoperative assessment of regional lung perfusion in 15 patients with NSCLC against dynamic contrast-enhanced MRI (DCE MRI). FD MRI provides high sensitivity (84%), specificity (92%) and accuracy (91%) in detecting lobar perfusion defects. Image quality of FD MRI has shown to be less than that of its reference DCE MRI. FD MRI can quantify bilateral and lobar perfusion proportions with sufficient accuracy in both upper lobes and for bilateral comparison, but is in its present form limited by pulsation artifacts in the lower parts of the lungs.