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Abstract #0650

Quantitative Analysis of Pulmonary Inflammation After Endobronchial Allergen Challenge Using T1-Mapping MRI

Julius Renne1, Jens Hohlfeld2, Jan Hinrichs1, Christian Schnfeld1, Marcel Gutberlet1, Carla Winkler3, Cornelia Faulenbach2, Peter M. Jakob4, Norbert Krug2, Frank Wacker1, Jens Vogel-Claussen1

1Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany; 2Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany; 3Dep. of Pneumology, Hannover Medical School, Hannover, Germany; 4Experimental Physics (Biophysics), University of Wrzburg, Wrzburg, Germany

Endobronchial allergen challenge is an established method for the evaluation of new anti-allergic drugs. Today the concentration of eosinophilic cells is the standard readout parameter for pulmonary inflammation. Therefore repeated bronchoscopies are needed, which are a substantial burden for volunteers. A new method for identification and quantification of the pulmonary inflammation after endobronchial challenge using oxygen-enhanced pulmonary MRI (T1-mapping) is presented.