Abstract #0650

Quantitative Analysis of Pulmonary Inflammation After Endobronchial Allergen Challenge Using T1-Mapping MRI

Julius Renne¹, Jens Hohlfeld², Jan Hinrichs¹, Christian Schnfeld¹, Marcel Gutberlet¹, Carla Winkler³, Cornelia Faulenbach², Peter M. Jakob⁴, Norbert Krug², Frank Wacker¹, Jens Vogel-Claussen¹

¹Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany; ²Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany; ³Dep. of Pneumology, Hannover Medical School, Hannover, Germany; ⁴Experimental Physics (Biophysics), University of Wrzburg, Wrzburg, Germany

Endobronchial allergen challenge is an established method for the evaluation of new anti-allergic drugs. Today the concentration of eosinophilic cells is the standard readout parameter for pulmonary inflammation. Therefore repeated bronchoscopies are needed, which are a substantial burden for volunteers. A new method for identification and quantification of the pulmonary inflammation after endobronchial challenge using oxygen-enhanced pulmonary MRI (T1-mapping) is presented.