1Chemical Physics, Weizmann Institute of Science, Rehovot, Israel; 2The MR Research Centre, Aarhus University, Aarhus, Denmark; 3Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark; 4GE healthcare, Broendby, Denmark
Fast and effective scanning methods are required for the hyperpolarized [1-13C]pyruvate dynamic metabolic imaging due to the short time available before the hyperpolarized signal decays. Recent studies described the potential of single-shot spatiotemporal encoding (SPEN) principles to derive chemical shift images. SPEN acquired signal contains the spatial and spectral information at no extra cost. Sequences with 180 chirp pulses were recently shown to yield single-shot chemical shift images. The present work demonstrates the first in-vivo results using a SPEN sequence; showing [1-13C]pyruvate and the metabolic derivatives in the kidneys after hyperpolarized [1-13C]pyruvate injection to healthy rats at 4.7T.