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Abstract #0655

Differentiation of Pyruvate Flux Versus Exchange in Rat Liver in vivo Using a Three-Site Exchange Model

Jae Mo Park1, 2, Ralph Hurd3, Kelvin Bilingsly1, Sonal Josan, 14, Yi-Fen Yen1, Dirk Mayer1, 4, Daniel Spielman1, 2

1Radiology, Stanford University, Stanford, CA, United States; 2Electrical Engineering, Stanford University, Stanford, CA, United States; 3Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 4Neuroscience Program, SRI International, Menlo Park, CA, United States

We propose an improved three-site exchange model that considers conversion between pyruvate, lactate, and alanine, and measure the ratio of flux and isotopic exchange among them by injecting co-polarized pairs of [2-13C]pyruvate and [1-13C]alanine, and [2-13C]pyruvate and [1-13C]lactate.