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Abstract #0717

Prediction of Response to Chemotherapy in Patients with Osteosarcoma and Ewings Sarcoma

Louisa Bokacheva1, Ya Wang1, Wei Huang2, David M. Panicek3, Jason A. Koutcher1, 3

1Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 2Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 3Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

DCE MRI was performed in 34 patients with osteosarcoma and Ewing's sarcoma before, during and after neoadjuvant chemotherapy. Patients underwent surgery with histological assessment of necrosis or radiation therapy and were followed up clinically for up to six years. Voxel parameters were derived from DCE MRI data using linearized form of the Tofts model and population-based arterial input function. The mean tumor Ktrans decreased significantly at the time of the third MRI session relative to baseline. Both the mean Ktrans value and percent decrease relative to baseline were predictive of histological response, but did not appear to predict survival.