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Abstract #0718

Differentiation of Myeloma and Metastatic Cancer in the Spine Using Dynamic Contrast Enhanced MRI

Ning Lang1, Min-Ying Su2, Hon J. Yu2, Muqing Lin2, Huishu Yuan1

1Department of Radiology, Peking University Third Hospital, Beijing, China; 2Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States

DCE-MRI was performed to differentiate between myelomas and metastatic cancers in the spine. The peak signal enhancement percentage (SE%), the steepest wash-in SE%, and the wash-out SE%, were calculated. The two-compartmental pharmacokinetic model was used to obtain Ktrans and kep. The myeloma group had a higher peak SE%, a higher wash-in and wash-out SE%, and also a higher Ktrans and kep. The ROC show that the AUC was 0.798 for Ktrans, 0.864 for kep, and 0.919 for combined Ktrans and kep. The results show that DCE-MRI may provide additional information for making differential diagnosis of spinal tumors.