Abstract #0720

Preliminary Analysis of Arterial Input Function Derived from Dynamic Contrast Enhanced MRI in Children with Cancer

Keiko Miyazaki¹, Matthew R. Orton¹, David John Collins¹, James A. d'Arcy¹, Toni Wallace², Lucas Moreno³, Andrew Pearson³, Stergios Zacharoulis³, Martin O. Leach¹, Dow-Mu Koh²

¹CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom; ²Department of Diagnostic Radiology, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; ³Department of Paediatric Oncology, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

The aim of this study is to investigate the feasibility and challenges of obtaining arterial input functions from paediatric DCE-MRI studies. Preliminary analysis of AIFs obtained from paediatric DCE-MRI data have shown it is possible to obtain consistent AIFs using a power injector. Inconsistencies in hand-injected AIFs found in this study have highlighted the need to optimize modes of contrast agent delivery through central lines. This is an ongoing study whereby further data will continue to be acquired in order to build a more representative paediatric population AIF that would enable quantitative DCE-MRI data analyses in paediatric clinical trial settings.