Abnormal Resting-State Default Mode Network Connectivity in Major Depressive Disorder: Multimodal EEG and BOLD fMRI Study

Han Yuan¹, Vadim Zotev¹, Raquel Phillips¹, Kymberly D. Young¹, Masaya Misaki¹, Jerzy Bodurka¹, ²

We acquired simultaneous EEG and BOLD fMRI in groups of major depressive (MDD) and healthy control subjects. We developed a multimodal analysis approach to investigate the abnormal resting-state default model network (DMN) connectivity in MDD. Our study revealed increased connectivity in the left superior frontal cortex, bilateral middle temporal gyri, and medial prefrontal cortex and decreased connectivity in the posterior cingulate cortex. Furthermore, joint analysis with EEG found that, in the regions with abnormal DMN connectivity, MDD subjects score of depression severity are positively correlated with the EEG-microstates-associated BOLD activity, but not with the DMN activity derived from BOLD alone.