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Abstract #0733

Dynamic T1rho Imaging in Panic Disorder

Vincent A. Magnotta1, 2, Casey P. Johnson1, Robin Follmer2, Simon Roh1, John A. Wemmie2

1Radiology, The University of Iowa, Iowa City, IA, United States; 2Psychiatry, The University of Iowa, Iowa City, IA, United States

The purpose of this study is to evaluate functional T1rho imaging in panic disorder. We used a visual flashing checkerboard to assess dynamic changes in the T1ρ relaxation parameter within the occipital cortex. In addition, BOLD and 31P spectroscopy were obtained using a similar paradigm. We found a significant increase in T1ρ relaxation in panic subjects as compared to controls during the visual activation task within the cuneus bilaterally and a significant decrease in the anterior cingulate bilaterally. In subjects with panic disorder, we found a significant relationship between the magnitude of the T1rho response and symptoms as measured with the Beck Anxiety Inventory. BOLD imaging did not reveal any significant relationships with symptoms.