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Abstract #0748

Intra-Individual Assessment of the Bolus Properties of 0.5M Gadopentetate Dimeglumine and 1.0M Gadobutrol in Time-Resolved Contrast-Enhanced 4D-MRA and Dynamic CT in a Minipig Model

Dariusch Reza Hadizadeh1, Gregor Jost2, Hubertus Pietsch2, Martin Weibrecht3, Marco Lierfeld4, Jack Boschewitz1, Hans H. Schild1, Winfried Albert Willinek1

1Radiology, University of Bonn, Bonn, NRW, Germany; 2MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany; 3Research Laboratories, Philips Technologie GmbH Innovative Technologies,, Aachen, NRW, Germany; 4Institute of Imaging & Computer Vision), RWTH Aachen University, Aachen, NRW, Germany

Time-resolved contrast-enhanced MRA (4D-MRA) is more and more applied in various clinical indications and optimization of the applied contrast agent bolus is crucial. The impact of 1molar concentration on vascular gadolinium concentration (dynamic CT) and signal levels (4D-MRA) was investigated in an animal model of 7 Goettinger minipigs. Transversal slices covered the ascending aorta, descending aorta, and pulmonary trunk. Signal levels, the bolus profile and Gd-concentrations were quantified using 1.0M Gadobutrol (1.0GB) and 0.5M gadopentetate dimeglumine (0.5GD). 4D-MRA offered significantly higher signal and dynamic CT allowed for quantification of respectively higher peak Gd-concentrations using 1.0GB vs. 0.5GD.