Anamolous Behavior of Lanthanide Chelates at 7T

Talaignair N. Venkatraman¹, Christopher D. Lascola²

In this study, we investigated both longitudinal and transverse relaxivities of Magnevist and Ablavar at clinically relevant concentrations in the presence and absence of human serum albumin (HSA) at 7.0T. These data reveal paradoxical behavior of Gadofovest in the presence of protein at higher field strength. The importance of measuring both r1 and r2 relaxivities at high field is also discussed. These data also emphasize the importance of examining both r1 and r2 relaxation properties of various lanthanide contrast agents in tandem, given that changes in these parameters do not necessarily occur in lockstep with each other at different field strengths.