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Abstract #0780

Mapping Putative Centrality Hubs in Rhesus Macaques and Humans Using Diffusion Tractography and Graph Theory

Longchuan Li1, Xiaoping P. Hu2, Todd Preuss3, 4, Matthew F. Glasser5, Frederick William Damen2, Yuxuan Qiu6, James Rilling4, 7

1Biomedical Imaging Technology Center, Emory University/Georiga Tech, Atlanta, GA, United States; 2Department of Biomedical Engineering, Emory University/Georgia Tech, Atlanta, GA, United States; 3Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 4Center for Translational and Social Neuroscience, Emory University, Atlanta, GA, United States; 5Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO, United States; 6School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, United States; 7Department of Anthropology, Emory University, Atlanta, GA, United States

Although brain networks derived via diffusion tractography have been widely used in ascertain brains structural connectivity, the accuracy of the networks has yet to be fully validated. We compared tractography- and tracer-derived brain networks of monkeys for evaluation purposes as well as the tractography-derived networks of monkeys and humans for insight into interspecies differences. A relatively good correspondence between the tracer- and tractography-derived brain networks of monkeys was noted. When comparing the networks from the two species, we found common hubs in the medial parietal cortex, but a discrepancy in the medial prefrontal cortex.