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Abstract #0781

A Critical Consideration on the Absence of Significance and the Impact of Structure Size When Interpreting DTI and DKI Results

Filip Szczepankiewicz1, Jimmy Ltt2, Ronnie Wirestam1, Alexander Leemans3, Pia Sundgren2, 4, Danielle van Westen2, 4, Freddy Sthlberg1, 4, Markus Nilsson1

1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2MR Department, Lund University Hospital, Lund, Sweden; 3Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 4Department of Diagnostic Radiology, Lund University, Lund, Sweden

DTI and DKI parameters are commonly used to compare brain tissue in patients and controls. Such comparisons are frequently based on statistical tests, but analysis of statistical power and potential confounders are often overlooked. In this study we use the cingulum to demonstrate how heterogeneity of the variability and structure size at various positions along the structure can influence the diffusion parameters with respect to both statistical power and interpretation of the results.