Abstract #0818

Single-Breath Gas and Dissolved-Phase 129Xe MRI in Healthy Subjects Using a 3D Radial Sequence: Effect of Posture on Signal Distribution

Suryanarayanan S. Kaushik¹,², Matthew S. Freeman,²³, Zackary I. Cleveland,²⁴, Rohan S. Virgincar², Scott H. Robertson,²³, John Davies⁵, Jane Stiles⁶, William Michael Foster⁶, H. Page McAdams⁴, Bastiaan Driehuys²,⁴

¹Biomedical Engineering, Duke University, Durham, NC, United States; ²Center For In Vivo Microscopy, Duke University, Durham, NC, United States; ³Medical Physics Graduate Program, Duke University, Durham, NC, United States; ⁴Radiology, Duke University, Durham, NC, United States; ⁵Respiratory Therapy, Duke University, Durham, NC, United States; ⁶Pulmonary Medicine, Duke University, Durham, NC, United States

In addition to its alveolar gas-phase resonance (0 ppm), ¹²⁹Xe dissolved in the pulmonary tissues gives rise to distinct resonances in the barrier tissue (197 ppm) and red blood cells (211 ppm). To quantify this dissolved ¹²⁹Xe distribution, the gas-phase image should be acquired in the same breath. To this end, we describe an interleaved 3D-radial acquisition that acquires isotropic images of both the dissolved and gas-phase ¹²⁹Xe. Using this acquisition, we probe the effect of the supine and prone posture on the dissolved-phase signal distribution.