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Abstract #0819

Diffusion-Weighted Hyperpolarized Helium-3 and Xenon-129 Magnetic Resonance Imaging of Elderly Never-Smokers and Ex-Smokers with Chronic Obstructive Pulmonary Disease

Miranda Kirby1, Sarah Svenningsen1, Alexei V. Ouriadov1, Giles E. Santyr1, David G. McCormack2, Grace Parraga1

1Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; 2Division of Respirology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada

Our objective was to compare hyperpolarized helium-3 (3He) magnetic resonance imaging (MRI) apparent diffusion coefficients (ADC) and xenon-129 (129Xe) ADC with a b-value of 12s/cm2, 20s/cm2 and 30s/cm2 in the same healthy volunteers and chronic obstructive pulmonary disease (COPD) ex-smokers to determine which b-value associated with 129Xe ADC provides the greatest relationship with 3He ADC and standard measures of lung function. For all subjects, 3He ADC was significantly correlated with 129Xe ADCb=12 (r=.98, p<.0001) and ADCb=20 (r=.91, p=.002). DLCO was significantly correlated with 3He ADC (r=-1.00, p<.0001), 129Xe ADCb=12 (r=-.98, p<.0001) and 129Xe ADCb=20 (r=-.89, p=.003).