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Abstract #0869

MRI Contrasts Generated Using Fictitious Fields in High-Rank Rotating Frames Correlate with Myelin Content in Normal Rat Brain ex vivo

Timo Liimatainen1, Alejandra Sierra1, Hanne Hakkarainen1, Djaudat Idiyatullin2, Christine Storino2, Silvia Mangia2, Olli Grhn1, Michael Garwood2, Shalom Michaeli2

1A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Fi, Finland; 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Relaxation Along a Fictitious Field (RAFF) was used to characterize MRI tissue contrast in a rotating frames of rank n, where n was varied between 1 and 5. Relaxation times maps in high-rank rotating frames correlate with myelin content in the rat brain ex vivo better than T1, T2, T1&[rho], T2&[rho] or MT. The RAFFn provides high potential for mapping of myelination in the brain.