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Abstract #0893

On the Comparability of Volumetric Brain Data in the Multicentric IMAGEN Study

Rdiger Brhl1, Albrecht Ihlenfeld1, Semiha Aydin1, Penelope A. Gowland2, Gareth John Barker3, Tomas Paus4, Jrgen Finsterbusch5, Simone Khn6, Jrgen Gallinat7, Arun Bokde8, Michael Smolka9, Frauke Nees10, Jean-Luc Martinot11, Gunter Schumann3, the IMAGEN Consortium3, Bernd Ittermann1

1PTB, Berlin, Germany; 2University of Nottingham, Nottingham, United Kingdom; 3Institute of Psychiatry, Kings College London, London, United Kingdom; 4Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada; 5University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 6Max-Planck-Institut fr Bildungsforschung, Berlin, Germany; 7Psychiatry and Psychotherapy, Charit Universittsmedizin, Berlin, Germany; 8Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland; 9Department of Psychology, Technische Universitt Dresden, Dresden, Germany; 10Central Institute of Mental Health, Mannheim, Germany; 11University Paris Descartes, Paris, France

The multicentre study IMAGEN scanned more than 2000 at 8 sites in Europe using scanners of 4 different manufactures. Freesurfer's volumetric results show significant differences between the sites and especially the scanner models. Data of phantoms and 2 traveling volunteers are used to explain these differences leading to the necessity of characterizing the gradient induced distortion field locally. Data of 2 new precision geometry phantoms will provide the information to finally decide whether the differences are artificial or sample generated.