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Abstract #0921

A Combined GABA-MRS and Behavioural Study in Children with Autism Spectrum Disorder

Nicolaas A. J. Puts1, 2, Taylor Koriakin, Ericka L. Wodka, Mark Tommerdahl3, Peter B. Barker1, 2, Stewart H. Mostofsky4, Richard Anthony Edward Edden1, 2

1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 2FM Kirby Centre for functional neuroimaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Biomedical engineering, University of North Carolina, Chapel hill, NC, United States; 4School of Medicine, Johns Hopkins University, Baltimore, MD, United States

GABA-MRS was combined with behavioural tactile measures in typically developing children and children with Autism Spectrum Disorder and showed a reduction in GABA concentration as well as a impairment in tactile processing in children with ASD.