A Study of Corpus Callosum Size and Shape in Early Alzheimers Disease

Babak A. Ardekani¹

Structural images from the OASIS brain MRI database were used to study the corpus callosum size, characterized by its mid-sagittal cross-sectional area (CCA), and shape, characterized by its circularity (CIR) in early Alzheimers disease (AD). The CCA and CIR were compared in 98 normal controls subjects, 70 patients with very mild AD, and 28 patients with mild AD. The CIR was significantly different between the two patients groups, while CCA differences were not statistically significant. The results suggest that CIR may be a more sensitive marker than CCA for monitoring the progression of AD.