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Abstract #1003

Establishing MRI Phase, Abnormal MRI Phase, and Volume Behavior in the Subcortical Deep Gray Matter of Healthy Individuals

Jesper Hagemeier1, Michael G. Dwyer1, Niels P. Bergsland1, Ferdinand Schweser2, Christopher R. no1, Mari Heininen-Brown1, Deepa P. Ramasamy1, Ellen Carl1, Cheryl Kennedy1, Mariya Cherneva1, Rebecca Melia1, Paul Polak1, Andreas Deistung3, Jrgen R. Reichenbach2, Robert Zivadinov1

1Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, Buffalo, NY, United States; 2Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Germany; 3Medical Physics Group, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

Brain iron levels have been shown to increase with age, and to be higher in age-related neurodegenerative disorders. To fully understand the pathology of increased iron concentration in neurodegenerative disorders, it is important to take a step back and investigate aging in healthy individuals. In the present work, we show strong associations between deep gray matter mean phase measures acquired using susceptibility-weighted imaging (SWI), indicative of increased iron levels, and age in healthy individuals. This relationship is non-linear, with the highest overall iron concentrations observed in middle-age, after which levels rebound. Iron content of tissues with very high iron levels is linearly related to age. A strong association is also observed with brain atrophy.