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Abstract #1022

Diffusion Tensor Imaging in Diabetes Mellitus Type 2 and Memory Impairment - Initial Findings -

Frank C.G. van Bussel1, Walter H. Backes1, Paul A.M. Hofman1, Harm J. van de Haar1, Martin P.J. van Boxtel2, Miranda T. Schram3, Coen D.A. Stehouwer3, Joachim E. Wildberger1, Jacobus F.A. Jansen1

1Radiology, MUMC+, Maastricht, Netherlands; 2Psychiatry and Neuropsychology, MUMC+, Maastricht, Netherlands; 3Internal Medicine, MUMC+, Maastricht, Netherlands

Diabetes Mellitus Type II (T2DM) is associated with accelerated cognitive decline. A prominently affected cognitive domain is memory, for which the hippocampus plays an essential role. DTI might be a good candidate for identification of early biomarkers of memory decline in T2DM. To the best of our knowledge, we are the first to use DTI to study microstructural properties of the hippocampus in T2DM patients with memory impairment, compared to healthy controls. This preliminary study showed that in the left hippocampus, a high MD was associated with poor memory performance, which suggests that injured hippocampal microstructure might underlie memory problems.