Feasibility of T1rho MR Imaging in Identification of the Epileptogenic Zone in Patients with Mesial Temporal Lobe Epilepsy

X. Li¹, V Lai¹, Queenie Chan², R.S.K. Chang³, Henry Ka Fung Mak¹, W. Mak³

In this study, we aim to test the feasibility of T1rho imaging in lateralization of epileptogenic zone in patients with mesial temporal lobe epilepsy. 7 patients with unilateral MR-positive MTLE and 7 normal subjects were recruited. T1rho imaging, T2 relaxometry and high resolution structural imaging were performed for all subjects. Four substructures of MTL, including hippocampal head/body/tail, and amygdala, were extracted and analyzed. Asymmetric ratios of corresponding substructures from both sides were calculated. Preliminary results demonstrated that T1rho imaging is a more sensitive and effective marker in lateralization of epileptogenic zone.