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Abstract #1023

Feasibility of T1rho MR Imaging in Identification of the Epileptogenic Zone in Patients with Mesial Temporal Lobe Epilepsy

X. Li1, V Lai1, Queenie Chan2, R.S.K. Chang3, Henry Ka Fung Mak1, W. Mak3

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China; 2Philips Healthcare, Hong Kong, China; 3Queen Mary Hospital, Hong Kong, China

In this study, we aim to test the feasibility of T1rho imaging in lateralization of epileptogenic zone in patients with mesial temporal lobe epilepsy. 7 patients with unilateral MR-positive MTLE and 7 normal subjects were recruited. T1rho imaging, T2 relaxometry and high resolution structural imaging were performed for all subjects. Four substructures of MTL, including hippocampal head/body/tail, and amygdala, were extracted and analyzed. Asymmetric ratios of corresponding substructures from both sides were calculated. Preliminary results demonstrated that T1rho imaging is a more sensitive and effective marker in lateralization of epileptogenic zone.