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Abstract #1031

GM and WM Changes Correlation with Duration in MSA-P: Comparison with DTI Changes

Bo Hou1, Han Wang2, Hui You1, Bo Jiang1, Feng Feng1

1Department of Radiology, Peking Union Medical College Hospital, Beijing, China; 2Department of Neurology, Peking Union Medical College Hospital, Beijing, China

For a MSA-P group and a control group, VBM, VBM regression with disease duration, and voxel-based analysis of DTI were performed, to compare the differences between the three methods in revealing the brain changes of the MSA patients.Finally,the results showed that DTI is more sensitive to brain changes in MSA-P, and could reveal larger area of abnormality. Also, DTI changes matched well with GM and WM lost revealed by VBM and VBM regression with duration,which meant that DTI could predict early brain changes in MSA-P.