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Abstract #1050

Diffusion Tensor Tractography Identifies Demyelination and Remyelination in the Spinal Cord of a Mouse Model of Multiple Sclerosis

Nabeela Nathoo1, Dayae Jeong2, Tad Foniok3, Michael B. Keough4, V. Wee Yong4, Jeffrey F. Dunn1, 5

1Radiology, University of Calgary, Calgary, Alberta, Canada; 2Rice University, Houston, TX, United States; 3National Research Council Canada, Calgary, Alberta, Canada; 4Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; 5Experimental Imaging Centre, University of Calgary, Calgary, Alberta, Canada

Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) visualize white matter tracts and use scalar values to inform on tissue integrity. Using a demyelinating animal model of multiple sclerosis (MS), the lysolecithin model, we observed that DTT enabled visual differentiation between demyelination and remyelination in a lesion in the spinal cord. Scalar values (FA, ADC, AD, RD, MD) were all found to be significantly different from a control area at the time of demyelination (p<0.01 for all), but not during remyelination. For the first time, we show that DTT can be used to assess demyelination/remyelination in the lysolecithin model.