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Abstract #1051

Amyloid Beta Causes Different Types of White Matter Damage Characterized by DTI

Hsiao-Fang Liang1, Jennifer Mei2, Dan Xu1, Wei-Xing Shi1, Shu-Wei Sun1, 2

1Loma Linda University, Loma Linda, CA, United States; 2University of California, Loma Linda, CA, United States

Intracerebroventricular injection of Amyloid Beta (Aβ) induced white matter damage in external capsule and optic tracts in mice. The damage was associated with an increased axial diffusivity in the external capsule and a decreased axial diffusivity in optic tract as detected by Diffusion Tensor Imaging (DTI). Our data suggested that axial diffusivity may serve as a marker for white matter damage in Alzheimers disease, capable of differentiating underlying pathological mechanisms.